Montelukast is a leukotriene receptor antagonist commonly prescribed for asthma and allergic rhinitis. However, in recent years, its potential neuropsychiatric side effects have raised significant concern. The U.S. Food and Drug Administration (FDA) has issued multiple warnings linking montelukast to depression, anxiety, insomnia, and even suicidal thoughts—effects that appear more pronounced in children and adolescents.Despite these risks, this does not mean all patients should stop taking the medication immediately. The decision to continue using montelukast should be based on an individual risk-benefit assessment. For mild asthma or allergy symptoms, doctors may recommend safer alternatives, such as inhaled corticosteroids or antihistamines. However, for some patients with severe asthma, montelukast may remain a crucial part of symptom control and can be continued under close medical supervision.Crucially, patients who experience mood changes, irritability, sleep disturbances, or unusual behaviors while taking montelukast should promptly inform their healthcare provider. Never discontinue the drug abruptly without medical advice, as this could trigger severe asthma exacerbations. In summary, montelukast can still be used—but only under a doctor’s guidance and with heightened awareness of its potential psychiatric side effects.
孟鲁司特（Montelukast）是一种常用于治疗哮喘和过敏性鼻炎的白三烯受体拮抗剂。然而，近年来其潜在的精神系统副作用引起了广泛关注。美国食品药品监督管理局（FDA）曾多次发布警告，指出孟鲁司特可能与抑郁、焦虑、失眠、甚至自杀意念等神经精神症状相关。这些不良反应在儿童和青少年中尤为明显。尽管存在风险，但并不意味着所有患者都应立即停药。是否继续使用孟鲁司特，需根据个体病情权衡利弊。对于轻度哮喘或过敏症状，医生可能会建议改用其他更安全的替代药物，如吸入性糖皮质激素或抗组胺药。但对于某些严重哮喘患者，孟鲁司特可能是控制病情的重要手段，此时应在密切监测下继续使用。关键在于：患者在服用孟鲁司特期间若出现情绪低落、烦躁不安、睡眠障碍或行为异常等症状，应立即告知医生。切勿自行停药，以免引发哮喘急性发作等严重后果。总之，孟鲁司特仍可使用，但必须在医生指导下，并高度警惕其潜在的精神副作用。
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